Cell Cycle/Checkpoint - Rho-kinase - MK2 - Rac - FGFR
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- B2219 EHop-0161 CitationTarget: RacSummary: Rac1/Rac3 GTPase抑制剂
- A3721 PHA-767491Target: Cyclin-Dependent Kinases|MK2|Cdc7Summary: Cdc7 / CDK9抑制剂
- A3478 Hydroxyfasudil中文名: 羟基法舒地尔Target: ROCK|Rho-kinaseSummary: Rho激酶抑制剂和血管扩张剂
- A4122 PHA-680632Target: Aurora Kinases|PLK|FGFRSummary: Aurora激酶抑制剂