Cell Cycle/Checkpoint - VEGFR - G-quadruplexes - Ubiquitin-activating Enzyme E1 - Myosin light chain kinases (MLCKs)
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- B3523 Fasudil中文名: 法舒地尔Target: ROCK|PKC|PKG|PKA|Myosin light chain kinases (MLCKs)Summary: 钙拮抗剂
- B1244 PYZD-4409Target: Ubiquitin-activating Enzyme E1Summary: 泛素激活酶E1抑制剂
- A3742 Pyridostatin2 CitationTarget: G-quadruplexesSummary: 促生长停滞药物
- A4125 CYC116Target: Aurora Kinases|FLT3|VEGFRSummary: Aurora A/B抑制剂