Cell Cycle/Checkpoint - Arp2/3 complex - Farnesyl Diphosphate Synthases - Microtubule/Tubulin
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- B2157 Cabazitaxel3 Citation中文名: 卡巴他赛Target: Microtubule/TubulinSummary: 微管相关抑制剂
- B3058 CK-6361 CitationTarget: Arp2/3 complexSummary: Arp2/3复合体抑制剂
- A1352 Zoledronic Acid中文名: 唑来膦酸Target: Farnesyl Diphosphate SynthasesSummary: 含氮二磷酸盐
- A1765 Vincristine sulfate中文名: 硫酸长春新碱Target: Microtubule/TubulinSummary: 微管的破坏者,抗肿瘤剂
- A3394 Epothilone D中文名: 埃博霉素 DTarget: Microtubule/TubulinSummary: 天然聚酮化合物