Proteases
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- B4790 Phosphoramidon Disodium Salt中文名: 磷酰二肽,膦酰二肽钠Target: metalloproteaseSummary: 金属蛋白酶抑制剂
- A1038 Amyloid β-Peptide (10-20) (human)Summary: 在阿尔茨海默病中引发神经退行性病变。
- B7393 GeduninTarget: HSP90Summary: 天然的Hsp90抑制剂
- B5780 UAMC 00039 dihydrochlorideTarget: Dipeptidyl-peptidase IISummary: 二肽基肽酶II(DPP-II)抑制剂
- B5657 MKT 077Summary: mortalin-2(mot-2)抑制剂
- B5415 PF 429242Summary: 甾醇调节元件结合蛋白(SREBP)位点1蛋白酶抑制剂
- B5153 Y-29794 oxalateSummary: 脯氨酰内肽酶的抑制剂
- B7719 TC-E 5006Summary: γ分泌酶调节剂
- B6689 Butabindide oxalateSummary: CCK失活丝氨酸蛋白酶(三肽基肽酶II)抑制剂
- A8170 Z-FA-FMKTarget: cysteine proteaseSummary: 半胱氨酸蛋白酶抑制剂