Neuroscience - Voltage-gated Potassium (KV) Channels - M2 Receptors - 5-HT4 Receptors
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B1610 Gallamine Triethiodide中文名: 加拉碘铵,弛肌碘,戈拉碘铵Target: M2 ReceptorsSummary: 胆碱能受体阻断剂
- B1198 CisaprideTarget: Voltage-gated Potassium (KV) Channels|5-HT4 ReceptorSummary: 5-HT4受体激动剂
- A8369 Atropine sulfate monohydrate中文名: 硫酸阿托品一水合物Target: M3 Receptors|M1 Receptors|M2 Receptors|M4 Receptors|M5 ReceptorsSummary: MAChRs拮抗剂
- A1334 Mosapride Citrate中文名: 莫沙必利柠檬酸盐Target: 5-HT3 Receptors|5-HT4 ReceptorsSummary: 5-HT受体激动剂