Neuroscience - 5-HT3 Receptors - dopamine receptor - GluR - AChR
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- C3869 BQCATarget: AChRSummary: M1毒蕈碱乙酰胆碱受体(mAChR)的正变构调节剂
- B6506 SCH 23390 hydrochlorideTarget: dopamine receptor|5-HT1 Receptor|5-HT2 ReceptorSummary: 多巴胺受体拮抗剂
- B1612 Pancuronium dibromide中文名: 泮库溴铵Target: AChRSummary: AChR拮抗剂
- B1616 Trospium chloride中文名: 曲司氯铵Target: AChRSummary: 抗毒蕈碱剂
- B1572 LatrepirdineTarget: Voltage-gated Calcium Channels (CaV)|NMDA receptor|adrenergic receptor|Histamine receptors|GluR|5-HT receptor|dopamine receptors|AMPA receptorSummary: 脑细胞死亡抑制剂
- B2241 Ondansetron中文名: 昂丹司琼Target: 5-HT3 ReceptorsSummary: 血清素5-HT3受体拮抗剂
- B2259 VUF 10166Target: 5-HT3 ReceptorsSummary: 5-HT3受体拮抗剂
- B2258 Tropisetron Hydrochloride中文名: 盐酸托烷司琼Target: 5-HT3 ReceptorsSummary: 5-HT3受体拮抗剂
- B1620 Tolterodine tartrate中文名: 酒石酸托特罗定Target: AChRSummary: 竞争性毒蕈碱受体拮抗剂
- A5220 Vecuronium Bromide中文名: 维库溴铵Target: AChRSummary: 非去极化神经肌肉松弛剂