Neuroscience - AChR - 5-HT2 Receptors - Cell Experiments
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- C3869 BQCATarget: AChRSummary: M1毒蕈碱乙酰胆碱受体(mAChR)的正变构调节剂
- B1612 Pancuronium dibromide中文名: 泮库溴铵Target: AChRSummary: AChR拮抗剂
- B1616 Trospium chloride中文名: 曲司氯铵Target: AChRSummary: 抗毒蕈碱剂
- B2248 Ketanserin中文名: 酮色林Target: 5-HT2 ReceptorsSummary: 特异性5-HT2A受体拮抗剂
- B2231 Amitriptyline HCl中文名: 盐酸阿米替林Target: Trk Receptors|5-HT2 Receptors|Norepinephrine transporter|5-HT TransportersSummary: 血清素/去甲肾上腺素受体/5-HT4/5-HT2抑制剂
- B2007 Pizotifen Malate中文名: 苹果酸苯噻Target: 5-HT2 Receptors|D2 ReceptorsSummary: 5-HT受体拮抗剂
- B1206 Pizotifen中文名: 苯噻啶Target: 5-HT2 ReceptorsSummary: 高选择性5-HT受体阻断剂
- B1477 Lurasidone HCl中文名: 盐酸鲁拉西酮Target: 5-HT2 Receptors|D2 Receptors|5-HT1 Receptors|5-HT7 ReceptorsSummary: 多巴胺D2/5-HT2A/5-HT7/5-HT1A抑制剂
- B1620 Tolterodine tartrate中文名: 酒石酸托特罗定Target: AChRSummary: 竞争性毒蕈碱受体拮抗剂
- B2235 Clozapine中文名: 氯氮平Target: 5-HT2 Receptors|D1 and D5 Receptors|D2 Receptors|D3 Receptors|5-HT1 Receptors|D4 ReceptorsSummary: 5-HT受体拮抗剂