Membrane Transporter/Ion Channel - GABAA receptor - Na /Ca2 Exchangers (NCXs) - cAMP - Myosin light chain kinases (MLCKs)
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- B2194 Tolbutamide中文名: 甲苯磺丁脲Target: cAMP|Sulfonylurea receptorsSummary: 第一代钾通道阻滞剂
- A3811 SEA04004 CitationTarget: Na /Ca2 Exchangers (NCXs)Summary: 特异性的Na+/Ca2+交换抑制剂
- A3626 ML-7 hydrochlorideTarget: Myosin light chain kinases (MLCKs)Summary: 肌球蛋白轻链激酶抑制剂
- A3401 Etifoxine hydrochloride中文名: 艾替伏辛盐酸盐Target: GABAA receptorSummary: GABAA受体增强剂