ZJ 43
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IC50: 2.4 nM。
ZJ-43是一种N-乙酰天冬氨酰谷氨酸(NAAG)肽酶抑制剂。
据报道,肽神经递质N-乙酰天冬氨酰谷氨酸(NAAG)是II组代谢型谷氨酸受体的一种激动剂。NAAG被细胞外肽酶活性灭活,导致产生谷氨酸和N-乙酰天冬氨酸。
体外:ZJ-43作为一种强效的谷氨酸羧肽酶II和III(GCP II和III)的抑制剂,Ki值分别为0.8和23 nM。ZJ-43通过与NMDA或代谢型谷氨酸受体的间接相互作用,抑制NAAG水解[1]。
体内:在大鼠神经病理性疼痛模型中,静脉注射ZJ-43能抑制爪注射福尔马林诱导的激越行为的两个阶段。此外,ZJ-43的静脉给药可减轻神经结扎诱导的机械异常性疼痛水平。ZJ-43在福尔马林试验和部分坐骨神经结扎模型中的这些作用被高选择性II组mGluR拮抗剂LY-341495的预处理完全拮抗[1]。
临床试验:N/A
参考文献:
[1] Yamamoto T1,Hirasawa S,Wroblewska B,Grajkowska E,Zhou J,Kozikowski A,Wroblewski J,Neale JH. Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model. Eur J Neurosci.2004 Jul;20(2):483-94.
Physical Appearance | White solid |
Storage | Store at -20°C |
M.Wt | 304.3 |
Cas No. | 723331-20-2 |
Formula | C12H20N2O7 |
Solubility | <30.43mg/ml in H2O; <30.43mg/ml in DMSO |
Chemical Name | (2S)-2-[[(1S)-1-carboxy-3-methylbutyl]carbamoylamino]pentanedioic acid |
SDF | Download SDF |
Canonical SMILES | CC(C)CC(C(=O)O)NC(=O)NC(CCC(=O)O)C(=O)O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |