THPP-1
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
THPP-1是一种有效的，具有选择性和口服活性的磷酸二酯酶10A (PDE10A) 抑制剂，对人和大鼠PDE10A的Ki分别为1 nM和1.3 nM。它也是一种SGC化学探针。TTHPP-1 显著增加了纹状体中与突触可塑性有关的蛋白质的磷酸化，包括 a-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid受体 (AMPA) GluR1 亚基、细胞外受体激酶 (ERK) 和 cAMP -反应元件结合蛋白（CREB）。 THPP-1 在预测抗精神病活性的临床前试验中，能产生剂量依赖性效应，包括减弱 MK-801 诱导的大鼠的精神运动激活和条件回避反应。在相似的血浆暴露下，THPP-1显著增加了大鼠的物体识别记忆，并在恒河猴中，减轻了氯胺酮诱导的物体提取迂回任务的缺陷。
1. Smith SM, et al. The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey. Neuropharmacology. 2013 Jan;64:215-23.
| Storage | Store at -20°C |
| M.Wt | 464.9 |
| Cas No. | 1257051-63-0 |
| Formula | C23H21ClN6O3 |
| Solubility | ≥11.93 mg/mL in DMSO |
| Chemical Name | (2-(6-chloropyridin-3-yl)-4-(2-methoxyethoxy)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)(imidazo[1,5-a]pyridin-1-yl)methanone |
| SDF | Download SDF |
| Canonical SMILES | O=C(N1CCC2=NC(C3=CC=C(Cl)N=C3)=NC(OCCOC)=C2C1)C4=C5C=CC=CN5C=N4 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
