Stachydrine (hydrochloride)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Stachydrine is an anti-metastatic agent.
Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits.
In vitro: The aim of a previous study was to investigate the effects of stachydrine (STA) on norepinephrine (NE) induced hypertrophy and the changes of calcium transients in neonatal rat cardiomyocytes. Results showed that NE treatment could increase protein synthesis, cell surface area, the expression level of β-MHC and β/α-MHC ratio and these effects were attenuated by STA treatment. In addition, NE-induced hypertrophy was associated with accelerated decay of Ca2+-transient, increased phospholamban expression, increased Ca2+-transient amplitude, hyper-phosphorylation, increased intracellular cAMP level, as well as PKA overactivation. All of these effects could be inhibited by STA treatment significantly [1].
In vivo: Previous study evaluated the effect of stachydrine on the expression of caspase-9 and 12 in rats with unilateral ureteral obstruction. Results showed that degree of renal interstitial fibrosis, serum creatinine, blood urea nitrogen, the renal tubular interstitial damage index, and expression of caspase-9 and 12 in the stachydrine-treatment groups were significantly decreased [2].
Clinical trial: So far, no clinical study has been conducted.
References:
[1] Zhang, C. ,Shan, X.-L.,Liao, Y.-L., et al. Effects of stachydrine on norepinephrine-induced neonatal rat cardiac myocytes hypertrophy and intracellular calcium transients. BMC Complement. Altern. Med. 14, 474 (2014).
[2] Zhang C, Lu Y, Zhou YJ, Tong QQ, Qu C, Kang TJ. The effect of stachydrine on the expression of caspase-12 in rats with unilateral ureteral obstruction. J Urol. 2014 Nov;192(5):1549-54.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 179.6 |
Cas No. | 4136-37-2 |
Formula | C7H13NO2·HCl |
Solubility | ≥8.73mg/mL in DMSO with ultrasonic; ≥7.06 mg/mL in EtOH with ultrasonic; ≥30.2 mg/mL in H2O |
Chemical Name | (2S)-2-carboxy-1,1-dimethyl-pyrrolidinium, inner salt, monohydrochloride |
SDF | Download SDF |
Canonical SMILES | C[N+]1(C)CCC[C@H]1C([O-])=O.Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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