SIN-1 chloride

SIN-1 chloride is an active metabolite of molsidomine, which is a potent vasorelaxant and inhibitor of platelet aggregation. It produces both NO and superoxide and can therefore be used to generate peroxynitrite under physiological conditions. SIN-1 decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion[1,2].

References:

[1]. Rosenkranz B, Winkelmann B R, Parnham M J. Clinical pharmacokinetics of molsidomine. Clinical Pharmacokinetics, 1996, 30(5): 372-384.

[2]. Lomonosova E E, Kirsch M, Rauen U, et al. The critical role of hepes in SIN-1 cytotoxicity, peroxynitrite versus hydrogen peroxide. Free Radical Biology & Medicine, 1998, 24(4): 522-528.