PTP1B-IN-2
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
PTP1B-IN-2 是一种有效的选择性蛋白酪氨酸磷酸酶-1B (PTP1B) 抑制剂，IC50 为 50 nM。 对细胞活性的进一步研究表明，PTP1B-IN-2 可以增强胰岛素介导的胰岛素受体 β (IRβ) 磷酸化和胰岛素刺激的葡萄糖摄取。 PTP1B-IN-2 深入活性位点口袋，与催化位点的关键残基形成若干氢键和疏水作用。 在15 μM和30 μM浓度下，PTP1B-IN-2可显著增强胰岛素介导的IRβ磷酸化。
1. Liu P, et al. Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity. Eur J Med Chem. 2016 Aug 8;118:27-33.
| Storage | Store at -20°C |
| M.Wt | 680.79 |
| Cas No. | 1919853-46-5 |
| Formula | C34H36N2O9S2 |
| Solubility | ≥49.3 mg/mL in DMSO |
| Chemical Name | methyl 5-(N-(4-(N-(2-methoxy-2-oxoethyl)methylsulfonamido)benzyl)-1-phenylmethylsulfonamido)-2-((4-methylbenzyl)oxy)benzoate |
| SDF | Download SDF |
| Canonical SMILES | COC(C(C=C(N(CC1=CC=C(N(CC(OC)=O)S(=O)(C)=O)C=C1)S(=O)(CC2=CC=CC=C2)=O)C=C3)=C3OCC4=CC=C(C=C4)C)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
