Protoporphyrin IX
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 100mg | ￥454.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Protoporphyrin IX, widely distributed in all living cells in small amounts, is the final intermediate of the heme biosynthetic pathway. Chelation of Protoporphyrin IX with iron forms heme, which is a constituent of hemoproteins that play essential roles in a variety of biological events, such as oxygen transport, cellular oxidations and reductions, electron transport, as well as drug metabolism. Based on its photodynamic effects, Protoporphyrin IX has also been explored for cancer diagnosis and treatment. However, accumulation of Protoporphyrin IX in human porphyrias can lead to a series of symptoms including skin photosensitivity, hepatobiliary damage, biliary stones, and even liver failure.
Reference:
1. Sachar M, Anderson KE, Ma X. Protoporphyrin IX: the Good, the Bad, and the Ugly. Journal of Pharmacology and Experimental Therapeutics, 2016, 356(2): 267-275.
产品性质
| 物理外观 | A solid |
| CAS号 | 553-12-8 |
| 分子式 | C34H34N4O4 |
| 分子量 | 562.66 |
| 溶解度 | insoluble in H2O; insoluble in EtOH; insoluble in DMSO |
| SMILES | O=C(CCC1=C2/C=C3C(CCC(O)=O)=C(C(/C=C(C(C)=C/4C=C)\NC4=C/C5=N/C(C(C=C)=C5C)=C\C(N2)=C1C)=N/3)C)O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 原卟啉 IX 是血红素生物合成途径的最后一个中间体，它是一种辐射敏化剂，即使在缺氧状态下也能增强 ROS 的生成，并诱导 DNA 损伤。原卟啉 IX 也是一种光敏剂，在光照射下会发生直接降解而产生光漂白。大鼠的肿瘤细胞在服用 5-氨基乙酰丙酸（5-ALA）（HY-W000450）后，会形成并积累原卟啉 IX。当红色荧光的峰值波长为 405 纳米时，原卟啉 IX 可选择性地改善基底细胞癌。原卟啉 IX 有望用于研究声动力和光动力制剂，以治疗多种癌症，如膀胱癌和结节性基底细胞癌。 |
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