sn-Glycerol-3-phosphate (cyclohexyl ammonium salt hydrate)
一种糖酵解与脂质代谢的关键化学中间体
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 100mg | ¥1200.00 | 10-15工作日发货 | |
| 250mg | ¥2412.00 | 10-15工作日发货 | |
| 500mg | ¥3570.00 | 10-15工作日发货 |
特色产品
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
产品描述
G3P是糖酵解与脂质代谢的关键化学中间体,具有多重生物活性与功能:参与甘油磷酸穿梭,实现 NADH 还原当量向氧化磷酸化途径的转移并再生 NAD⁺;作为合成生物学中活性氧研究的底物,可用于评估心脏组织的 G3P 可用性;是细胞内甘油磷酸酰基转移酶的底物,影响胰岛素生成,且对植物系统性获得抗性至关重要;其水平异常还与阿尔茨海默病、额叶痴呆及路易体痴呆患者的唾液变化相关,在脂质生物合成等代谢途径及疾病机制中发挥核心作用。
参考文献:
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[2] Cottingham IR, Ragan CI. Purification and properties of L-3-glycerophosphate dehydrogenase from pig brain mitochondria. Biochem J. 1980 Oct 15;192(1):9-18. doi: 10.1042/bj1920009. PMID: 6796038; PMCID: PMC1162302.
[3] Shen W, Wei Y, Dauk M, Tan Y, Taylor DC, Selvaraj G, Zou J. Involvement of a glycerol-3-phosphate dehydrogenase in modulating the NADH/NAD+ ratio provides evidence of a mitochondrial glycerol-3-phosphate shuttle in Arabidopsis. Plant Cell. 2006 Feb;18(2):422-41. doi: 10.1105/tpc.105.039750. Epub 2006 Jan 13. PMID: 16415206; PMCID: PMC1356549.
[4] Yeh JI, Chinte U, Du S. Structure of glycerol-3-phosphate dehydrogenase, an essential monotopic membrane enzyme involved in respiration and metabolism. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3280-5. doi: 10.1073/pnas.0712331105. Epub 2008 Feb 22. PMID: 18296637; PMCID: PMC2265192.
[5] Mráček T, Drahota Z, Houštěk J. The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues. Biochim Biophys Acta. 2013 Mar;1827(3):401-10. doi: 10.1016/j.bbabio.2012.11.014. Epub 2012 Dec 7. PMID: 23220394.
[6] Scott A, Noga MJ, de Graaf P, Westerlaken I, Yildirim E, Danelon C. Cell-Free Phospholipid Biosynthesis by Gene-Encoded Enzymes Reconstituted in Liposomes. PLoS One. 2016 Oct 6;11(10):e0163058. doi: 10.1371/journal.pone.0163058. PMID: 27711229; PMCID: PMC5053487.
[7] Madungwe NB, Zilberstein NF, Feng Y, Bopassa JC. Critical role of mitochondrial ROS is dependent on their site of production on the electron transport chain in ischemic heart. Am J Cardiovasc Dis. 2016 Sep 15;6(3):93-108. PMID: 27679744; PMCID: PMC5030389.
[8] Morita SY, Ueda K, Kitagawa S. Enzymatic measurement of phosphatidic acid in cultured cells. J Lipid Res. 2009 Sep;50(9):1945-52. doi: 10.1194/jlr.D900014-JLR200. Epub 2009 Apr 15. PMID: 19369695; PMCID: PMC2724771.
[9] Yang Y, Zhao J, Liu P, Xing H, Li C, Wei G, Kang Z. Glycerol-3-phosphate metabolism in wheat contributes to systemic acquired resistance against Puccinia striiformis f. sp. tritici. PLoS One. 2013 Nov 29;8(11):e81756. doi: 10.1371/journal.pone.0081756. PMID: 24312351; PMCID: PMC3843702.
[10] Mugabo Y, Zhao S, Seifried A, Gezzar S, Al-Mass A, Zhang D, Lamontagne J, Attane C, Poursharifi P, Iglesias J, Joly E, Peyot ML, Gohla A, Madiraju SR, Prentki M. Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytes. Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):E430-9. doi: 10.1073/pnas.1514375113. Epub 2016 Jan 11. PMID: 26755581; PMCID: PMC4743820.
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产品性质
| 分子式 | C3H9O6P • 2C6H13N [XH2O] |
| 分子量 | 370.43 (free acid) |
| 化学名称 | 1,2R,3-propanetriol, 1-(dihydrogen phosphate), cyclohexanamine, hydrate (1:2:X) |
| SMILES | OC[C@@H](O)COP(O)(O)=O.NC1CCCCC1.NC2CCCCC2.O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |



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