CMPF
呋喃脂肪酸的内源性代谢物
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 500ug | ￥401.00 | 现货 | |
| 1mg | ￥768.00 | 现货 | |
| 5mg | ￥3214.00 | 现货 | |
| 10mg | ￥5625.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
CMPF is an endogenous metabolite of furan fatty acids. CMPF is highly bound to albumin. Its main role is to inhibit cell transport and subsequent deiodination of thyroxine (T4)[1].
CMPF can effectively replace the competitive T4 binding molecules in albumin and play a role by indirectly binding albumin. And CMPF can inhibit the binding of T4 and albumin by increasing the serum concentration of competitive binding molecules such as oleic acid[2].
References:
[1]. Lim C, Bernard B F, De Jong M, et al. A furan fatty acid and indoxyl sulfate are the putative inhibitors of thyroxine hepatocyte transport in uremia. The Journal of Clinical Endocrinology and Metabolism, 1993, 76(2): 318-324.
[2]. Lim C F, Stockigt J R, Curtis A J, et al. A naturally occuring furan fatty acid enhances drug inhibition of thyroxine binding in serum. Metabolism, 1993, 42(11): 1468-1474.
产品性质
| 物理外观 | A crystalline solid |
| CAS号 | 86879-39-2 |
| 分子式 | C12H16O5 |
| 分子量 | 240.25 |
| 化学名称 | 2-(2-carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic acid |
| 溶解度 | insoluble in H2O; ≥48.4 mg/mL in EtOH; ≥49.4 mg/mL in DMSO |
| SMILES | CCCC1=C(C)C(C(O)=O)=C(CCC(O)=O)O1 |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | CMPF 是一种微管蛋白抑制剂；可用于研究肿瘤。 |
生物相关数据
质量控制
操作说明
APExBIO 顾客使用本产品发表的 3 篇科研文献
- 1. Yuanyuan Shi, Huajun Tian, et al. "Improved Dialysis Removal of Protein-Bound Uraemic Toxins with a Combined Displacement and Adsorption Technique." Blood Purif. 2022;51(6):548-558. PMID:34515053
- 2. Shi Y, Zhang Y, et al. "Improved dialytic removal of protein-bound uremic toxins by intravenous lipid emulsion in chronic kidney disease rats." Nephrol Dial Transplant. 2019 May 9. pii: gfz079. PMID:31071223
- 3. Shi Y, Tian H, et al. "Effect of Ionic Strength, pH and Chemical Displacers on the Percentage Protein Binding of Protein-Bound Uremic Toxins." Blood Purif. 2018 Dec 18:1-10. PMID:30562731
沪公网安备 31011002003500