Aldosterone
主要的盐皮质激素，控制钠和钾平衡
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 500ug | ￥1500.00 | 10-15工作日发货 | |
| 1mg | ￥2625.00 | 10-15工作日发货 | |
| 5mg | ￥5000.00 | 10-15工作日发货 | |
| 10mg | ￥8250.00 | 10-15工作日发货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Aldosterone is a steroid hormone secreted by the adrenal cortex and is the principle mineralocorticoid controlling sodium and potassium balance[1].
In vascular smooth muscle cells, aldosterone inhibits nitrite production in a dose-dependent manner, which is induced by interleukin-1β (IL-1β). Aldosterone inhibits mRNA expression of NO synthase. And reduce the accumulation of nitric oxide synthase protein. In conclusion, aldosterone inhibits NO synthesis in vascular smooth muscle cells under IL-1β stimulated conditions[2].
Aldosterone (0.72 mg/kg/day, 14 days) caused a slight increase in blood pressure in male mice (14 mmHg). Aldosterone can also increase the production of superoxide in the cerebral arteries of mice and promote mRNA expression of chemokine (C-C motif) ligand 7 (CCL7), CCL8 and IL-1β in the brain[3].
References:
[1]. Agarwal M K, Mirshahi M. General overview of mineralocorticoid hormone action. Pharmacology & Therapeutics, 2000, 84(3): 273-326.
[2]. Ikeda U, et al. Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Eur J Pharmacol. 1995, 290(2): 69-73.
[3]. Dinh Q N, et al. Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor. Brain Res, 2016, 1637: 146-153.
产品性质
| 物理外观 | A crystalline solid |
| CAS号 | 52-39-1 |
| 分子式 | C21H28O5 |
| 分子量 | 360.44 |
| 化学名称 | (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-13-carbaldehyde |
| 溶解度 | ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide |
| SMILES | O=C1CC[C@]2(C(CC[C@@]3([C@@]2([C@H](C[C@]4([C@]3(CC[C@@H]4C(CO)=O)[H])C([H])=O)O)[H])[H])=C1)C |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 醛固酮是主要的矿皮质激素。醛固酮是肾上腺皮质的肾小球膜在肾素-血管紧张素系统激活或饮食中摄入高钾时合成和分泌的。 |
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