MitoTEMPO (hydrate)
MitoTEMPO (hydrate)
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 1mg | ￥705.00 | 现货 | |
| 5mg | ￥1469.00 | 现货 | |
| 10mg | ￥2527.00 | 现货 | |
| 25mg | ￥4350.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
MitoTEMPO is a mitochondria-targeted antioxidant that possesses superoxide and alkyl radical scavenging properties[1]. This compound combines the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria.1 Mitochondrial targeting of superoxide scavenging via mitoTEMPO has been examined for potential therapeutic benefit to a variety of mitochondrial dysfunctions arising from excessive reactive oxygen species[2-4].
References：
[1]. Dikalov S. Cross talk between mitochondria and NADPH oxidases. Free Radical Biology and Medicine, 2011, 51(7): 1289-1301.
[2]. Liang H L, Arsenault J R, Mortensen J, et al. Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells. Apoptosis, 2009, 14(10): 1176-1189.
[3]. Dikalova A E, Bikineyeva A T, Budzyn, K, et al. Therapeutic targeting of mitochondrial superoxide in hypertension. Circulation Research, 2010, 107(1): 106-116.
[4]. Liang H L, Sedlic F, Bosnjak Z J, et al. SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery. Free Radical Biology and Medicine, 2010, 49(10): 1550-1560.
产品性质
| 物理外观 | A crystalline solid |
| CAS号 | 1569257-94-8 |
| 分子式 | C29H37ClN2O3P |
| 分子量 | 528.04 |
| 化学名称 | A name could not be generated for this structure. |
| 溶解度 | ≥53.2 mg/mL in DMSO; ≥55.4 mg/mL in EtOH; ≥53.7 mg/mL in H2O |
| SMILES | O=C(NC1CC(C)(C)N([O])C(C)(C)C1)C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.[Cl-].O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
生物相关数据
操作说明
APExBIO 顾客使用本产品发表的 5 篇科研文献
- 1. Tao Chen, Dongbao Li, et al. "Loss of NDUFS1 promotes gastric cancer progression by activating the mitochondrial ROS-HIF1α-FBLN5 signaling pathway." Br J Cancer. 2023 Oct;129(8):1261-1273. PMID: 37644092
- 2. Yejia Chen, Xiaobo Li, et al. "Complement C5a induces the generation of neutrophil extracellular traps by inhibiting mitochondrial STAT3 to promote the development of arterial thrombosis." Thromb J. 2022 Apr 29;20(1):24. PMID: 35488279
- 3. Jia X, Qiu T, et al. "Arsenic induces hepatic insulin resistance via mtROS-NLRP3 inflammasome pathway." J Hazard Mater. 2020;399:123034. PMID: 32544768
- 4. Tian C, Huang R, et al. "Transient Receptor Potential Ankyrin 1 Contributes to Lysophosphatidylcholine-Induced Intracellular Calcium Regulation and THP-1-Derived Macrophage Activation." J Membr Biol. 2020 Feb;253(1):43-55. PMID: 31820013
- 5. Wei S, Qiu T, et al. "Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway." J Hazard Mater. 2020;384:121390. PMID: 31735470
沪公网安备 31011002003500