α,α-Trehalose 6-phosphate potassium

Trehalose 6-phosphate (T6P) is synthesised from glucose-6-phosphate (G6P) and uridine 5-diphospho-glucose. Trehalose-6-phosphate synthase catalyzes this reaction[1]. T6P serves as a precursor for the synthesis of trehalose. It regulates sugar metabolism in in Arabidopsis plants and promotes its growth[2]. In plants, T6P blocks the action of sucrose nonfermenting-1-related protein kinase 1, which affects the energy and carbon metabolism[3].

Trehalose 6-phosphate (potassium salt) has been used as a standard to measure T6P concentrations in potato tubers[3]. It has also been used as a calibration standard in LC-MS assay for measurement of T6P in plants[4].

References:

[1]. Mata A T, Jorge T F, Ferreira J, et al. Analysis of low abundant trehalose-6-phosphate and related metabolites in Medicago truncatula by hydrophilic interaction liquid chromatography–triple quadrupole mass spectrometry. Journal of Chromatography A, 2016, 1477(31): 30-38.

[2]. Kolbe A, Tiessen A, Schluepmann H, et al. Trehalose 6-phosphate regulates starch synthesis via posttranslational redox activation of ADP-glucose pyrophosphorylase. Proceedings of the National Academy of Sciences, 2005, 102(31): 11118-11123.

[3]. Zsófia Juhász, Dirk Balmer, Anita Sós-Hegedűs, et al. Effects of drought stress and storage on the metabolite and hormone contents of potato tubers expressing the yeast trehalose-6-phosphate synthase 1 gene. Journal of Agricultural Science, 2014, 6(5): 142-142.

[4]. Mata A T, Jorge T F, Ferreira J, et al. Analysis of low abundant trehalose-6-phosphate and related metabolites in Medicago truncatula by hydrophilic interaction liquid chromatography–triple quadrupole mass spectrometry. Journal of Chromatography A, 2016, 1477(4): 30-38.