POM 1
Ecto-NTPDase抑制剂
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 1mL(10 mM in DMSO) | ￥299.00 | 现货 | |
| 10mg | ￥199.00 | 现货 | |
| 25mg | ￥299.00 | 现货 | |
| 50mg | ￥399.00 | 现货 | |
| 100mg | ￥499.00 | 现货 | |
| 250mg | ￥799.00 | 现货 | |
| 500mg | ￥999.00 | 现货 | |
| 1g | ￥1100.00 | 现货 | |
| 5g | ￥1499.00 | 现货 | |
| 10g | 请咨询 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
POM 1, also known as sodium polyoxotungstate and sodium metatungstate, is a novel, potent inhibitor of ecto-nucleoside triphosphate diphosphohydrolases (Ecto-NTPDases). POM 1 exhibits minor selectivity for NTPDase 1 and NTPDase 3 over NTPDase 2, with Ki values being 2.58, 28.8 and 3.26 μM for NTPDase 1 (CD39), NTPDase 2 and NTPDase 3, respectively. Ecto-NTPDases capable of hydrolyzing nucleoside tri- and diphosphates are able to reduce the effective concentration of the released nucleotide, and inhibitors of Ecto-NTPDases can thus serve as valuable tools for amplifying the biological effects triggered by extracellularly released nucleotides.
References:
1. Müller CE, Iqbal J, Baqi Y, et al. Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorganic & Medicinal Chemistry Letters, 2006, 16(23): 5943-5947.
2. Wall MJ, Wigmore G, Lopatár J, et al. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. Neuropharmacology, 2008, 55(7): 1251-1258.
产品性质
| 物理外观 | A solid |
| CAS号 | 12141-67-2 |
| 分子式 | H2O40Na6W12 |
| 分子量 | 2986.01 |
| 小分子别名 | Sodium metatungstate |
| 溶解度 | ≥149.3 mg/mL in DMSO with ultrasonic; insoluble in EtOH; ≥65.4 mg/mL in H2O |
| SMILES | [Na+].O=[W+4]1234[O-2][W+4]567(=O)[O-2][W+4]89%10(=O)[O-2][W+4]%11%12(=O)([O-2]1)[O-2][W+4]%13(=O)([O-2]8)([O-2][W+4]%14%15%16(=O)[O-2][W+4]%17(=O)([O-2]2)([O-2]%11)[O-2][W+4]%18(=O)([O-2][W+4](=O)([O-2]3)([O-2]5)([O-2][W+4]%19%20(=O)([O-2][W+4]%21(=O)([O-2]6)([O-2]9)[O-2][W+4](=O)([O-2]%13)([O-2]%14)([O-2]%19)[OH-]%21%20)[O-2]%18)[O-2]47)([O-2]%15)[OH-]%17%16)[O-2]%12%10 |
| 存储条件 | 室温 |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 偏钨酸钠（多氧钨酸钠）是一种 NTPDase 抑制剂；对 NTPDase 1（CD39）、NTPDase 3 和 NTPDase 2 的 Ki 值分别为 2.58 μM、3.26 μM 和 28.8 μM。偏钨酸钠具有抗炎和抗癌作用。偏钨酸钠能抑制 ATP 分解；还能阻断中枢突触传递。 |
沪公网安备 31011002003500