O-Phosphorylethanolamine
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 100mg | ￥297.00 | 现货 | |
| 500mg | ￥809.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
O-Phosphorylethanolamine, also known as O-phosphoethanolamine, is an endogenous phospholipid metabolite. O-Phosphorylethanolamine serves as a precursor in the biosynthesis of phosphatidylethanolamine which is the most abundant lipid on the cytoplasmic layer of cellular membranes, with significant roles in a variety of cellular processes such as membrane fusion, cell cycle, autophagy, and apoptosis. In postmortem brain samples from patients with Alzheimer's disease and Huntington's disease, it can be observed that levels of O-phosphorylethanolamine are significantly reduced, which is accompanied by increased neuronal death. In addition, lower levels of O-phosphorylethanolamine have also been found in the midbrain and the cerebrospinal fluid of patients with Parkinson’s disease.
References:
1. Pavlovic Z, Bakovic M. Regulation of Phosphatidylethanolamine Homeostasis—The Critical Role of CTP:Phosphoethanolamine Cytidylyltransferase (Pcyt2). International Journal of Molecular Sciences, 2013, 14(2): 2529-2550.
2. Ellison DW, Beal MF, Martin JB. Phosphoethanolamine and ethanolamine are decreased in Alzheimer's disease and Huntington's disease. Brain Research, 1987, 417(2): 389-392.
3. Patel D, Witt SN. Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease. Oxidative Medicine and Cellular Longevity, 2017, 2017: 4829180.
产品性质
| 物理外观 | A solid |
| CAS号 | 1071-23-4 |
| 分子式 | C2H8NO4P |
| 分子量 | 141.06 |
| 小分子别名 | Phosphorylethanolamine |
| 化学名称 | 2-aminoethyl dihydrogen phosphate |
| 溶解度 | insoluble in EtOH; ≥3.53 mg/mL in DMSO with gentle warming and ultrasonic; ≥42.6 mg/mL in H2O |
| SMILES | NCCOP(O)(O)=O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 磷脂酰乙醇胺（磷酸单胺乙基酯）是一种膜磷脂，也是磷脂酰胆碱（HY-B2233B）的重要前体。它存在于大多数动物组织和各种人类颅外肿瘤中，在膜完整性、细胞分裂、线粒体呼吸功能等方面发挥着关键作用。研究表明，磷脂酰乙醇胺丰度的变化与阿尔茨海默病和帕金森病有关。降低肝脏中磷脂酰乙醇胺与磷脂酰胆碱的比例可以改善胰岛素信号传导。磷脂酰乙醇胺有望用于癌症、神经退行性疾病和代谢性疾病领域的研究。 |
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