NQ301
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
NQ301是一种抗血栓药物，可抑制兔血小板中的血栓烷A2受体和合酶活性, 具有抑制血栓素A2/前列腺素H2受体阻断血栓素A2合成酶活性，调节花生四烯酸释放和12-羟基-5、8、10、14-二十碳四烯酸形成的潜能。NQ301浓度依赖性抑制胶原蛋白诱导的洗涤兔血小板聚集，IC50值为10 mg/ml[1]。
NQ301显著抑制胶原蛋白-、凝血酶-、花生四烯酸-、thapsigargin-和钙离子载体a23187诱导的人血小板聚集，IC50值分别为13.0+/-0.1、11.2+/-0.5、21.0+/-0.9、3.8+/-0.1和46.2+/-0.8 mM[2]。
[1]. Jin YR, Cho MR, Lee KS, Lee JJ, Lim Y, Han XH, Oh KW, Hong JT, Yoo HS, Yun YP. An antithrombotic agent, NQ301, inhibits thromboxane A2 receptor and synthase activity in rabbit platelets. Basic Clin Pharmacol Toxicol. 2005 Sep;97(3):162-7. doi: 10.1111/j.1742-7843.2005.pto_973123.x. PMID: 16128910.
[2]. Zhang YH, Chung KH, Ryu CK, Ko MH, Lee MK, Yun YP. Antiplatelet effect of 2-chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone (NQ301): a possible mechanism through inhibition of intracellular Ca2+ mobilization. Biol Pharm Bull. 2001 Jun;24(6):618-22. doi: 10.1248/bpb.24.618. PMID: 11411547.
| Storage | Store at -20°C |
| M.Wt | 325.75 |
| Cas No. | 130089-98-4 |
| Formula | C18H12ClNO3 |
| Solubility | ≥16.7 mg/mL in DMSO |
| Chemical Name | 2-((4-acetylphenyl)amino)-3-chloronaphthalene-1,4-dione |
| SDF | Download SDF |
| Canonical SMILES | O=C1C(NC2=CC=C(C(C)=O)C=C2)=C(Cl)C(C3=C1C=CC=C3)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
