N-Acetylserotonin
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
N-Acetylserotonin is an agonist at the melatonin receptors MT1, MT2, and MT3.
A melatonin receptor is a G protein-coupled receptor binding melatonin. Three types of melatonin receptor have been identified. The MT1 and MT2 receptor subtypes are in humans and other mammals, whereas an additional melatonin receptor subtype MT3 has been identified in amphibia and birds.
In vitro: N-Acetylserotonin, a precursor of melatonin, was acetylated from serotonin by arylalkylamine Nacetyltransferase (AANAT). N-Acetylserotonin was found to be able to swiftly activate TrkB in a circadian manner. N-Acetylserotonin also exhibited antidepressant effect in a TrkB-dependent manner. In additioin, N-acetylserotonin could rapidly activate TrkB, but not TrkA or TrkC, in a neurotrophin- and MT3 receptor-independent manner. Moreover, N-acetylserotonin, but not melatonin, showed a robust antidepressant-like behavioral effect in a TrkB-dependent way [1].
In vivo: Animal study found that in BDNF knockout mice the administration of N-acetylserotonin could activate TrkB. Moreover, the endogenous TrkB was activated in wild-type C3H/f+/+ mice but not in AANAT-mutated C57BL/6J mice, in a circadian rhythm. In addition, TrkB activation was found to be high at night in the dark and low during the day [1].
Clinical trial: So far, no clinical study has been conducted.
Reference:
[1] Jang, S. W.,Liu, X.,Pradoldej, S., et al. N-acetylserotonin activates TrkB receptor in a circadian rhythm. Proceedings of the National Academy of Sciences of the United States of America 107(8), 3876-3881 (2010).
Storage | Store at -20°C |
M.Wt | 218.3 |
Cas No. | 1210-83-9 |
Formula | C12H14N2O2 |
Synonyms | N-Acetyl-5-hydroxytryptamine,NAS |
Solubility | insoluble in H2O; ≥11.5 mg/mL in EtOH; ≥33.65 mg/mL in DMSO |
Chemical Name | N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-acetamide |
SDF | Download SDF |
Canonical SMILES | OC1=CC=C(NC=C2CCNC(C)=O)C2=C1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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