MMP-9-IN-1
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
MMP-9-IN-1（OUN87710）是基质金属蛋白酶-9（MMP-9）的抑制剂，它特异性结合MMP-9的PEX结构域，但不结合其他MMP。MMP-9与MMP-9-IN-1结合的Kd为2.1±0.2μM。该化合物与PEX结构域之间的这种相互作用，导致MMP-9同源二聚化的消除，并导致MMP-9介导的细胞迁移所需的下游信号通路的阻断。经MMP-9-IN-1处理的HT-1080和MDA-MB-435细胞的增殖受到显著抑制。此外，MDA-MB-435 细胞用 GFP cDNA 稳定转染并皮下植入雌性免疫缺陷小鼠的乳腺脂肪垫内，MMP-9-IN-1的治疗削弱了 MMP-9 对原发肿瘤生长和转移的体内作用。在14周内，MMP-9-IN-1治疗的小鼠体重无明显变化，也未观察到其他毒性迹象。
1. Dufour A, et al. Small-molecule anticancer compounds selectively target the hemopexin domain of matrix metalloproteinase-9. Cancer Res. 2011 Jul 15;71(14):4977-88.
| Storage | Store at -20°C |
| M.Wt | 369.39 |
| Cas No. | 502887-71-0 |
| Formula | C16H17F2N3O3S |
| Solubility | ≥9.18 mg/mL in DMSO with ultrasonic |
| Chemical Name | N-(4-(difluoromethoxy)phenyl)-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamide |
| SDF | Download SDF, |
| Canonical SMILES | O=C(CSC1=NC(CCC)=CC(N1)=O)NC2=CC=C(OC(F)F)C=C2 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
