Mitochonic acid 5
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
线粒体酸5 (MA-5)与线粒体结合并改善肾小管和心肌细胞损伤。MA-5可以调节线粒体ATP合成[1]。MA-5通过 MAPK-ERK-Yap信号通路通过Bnip3调节线粒体自噬。抑制该信号通路或敲低Bnip3的表达可防止MA-5 对线粒体稳态和增加小胶质细胞凋亡产生有益影响[2]。MA-5在缺血再灌注损伤模型和顺铂诱导肾病模型中可改善肾功能。Mitochonic acid 5的口服给药在1小时的峰值时间以剂量反应方式增加血浆浓度[1]。
参考文献：
[1]. Suzuki T, et al. Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage. J Am Soc Nephrol. 2016 Jul;27(7):1925-32. PMID: 26609120
[2]. Lei Q, et al. Mitochonic acid 5 activates the MAPK-ERK-yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy. Cell Mol Biol Lett. 2018 Apr 5;23:14. PMID: 29636771
| Storage | Store at -20°C |
| M.Wt | 329.3 |
| Cas No. | 1354707-41-7 |
| Formula | C18H13F2NO3 |
| Synonyms | MA-5 |
| Solubility | ≥36.4 mg/mL in DMSO |
| Chemical Name | 4-(2,4-difluorophenyl)-2-(1H-indol-3-yl)-4-oxobutanoic acid |
| SDF | Download SDF |
| Canonical SMILES | O=C(O)C(CC(C1=CC=C(F)C=C1F)=O)C2=CNC3=C2C=CC=C3 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
