LY2608204
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
LY2608204是一种新型有效的葡糖激酶(GK)激活剂,EC50值为42 nM[1].
LY2608204是一种新型有效的葡糖激酶(GK)刺激物,在低葡萄糖浓度下EC50值为42 nM.此外,在大鼠胰岛瘤INS1-E细胞系中,LY2608204可激活葡萄糖代谢,EC50值为579 nM,除此之外,LY2608204可以剂量依赖的方式降低空腹和餐后血糖水平[1].
参考文献：
[1] KJ Filipski, BD Stevens . Glucokinase activators in development .2012 books
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 559.81 |
| Cas No. | 1234703-40-2 |
| Formula | C28H37N3O3S3 |
| Solubility | ≥28.35 mg/mL in DMSO; insoluble in H2O; ≥26.2 mg/mL in EtOH |
| Chemical Name | (1R,2S)-2-cyclohexyl-1-(4-cyclopropylsulfonylphenyl)-N-[5-(2-pyrrolidin-1-ylethylsulfanyl)-1,3-thiazol-2-yl]cyclopropane-1-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | C1CCC(CC1)C2CC2(C3=CC=C(C=C3)S(=O)(=O)C4CC4)C(=O)NC5=NC=C(S5)SCCN6CCCC6 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | LY2608204是葡糖激酶(GK)的激活剂,EC50值为42 nM. | |||||
| 靶点 | GK | |||||
| IC50 | 42 nM(EC50) | |||||
质量控制和MSDS
- 批次:
化学结构
