切换导航
关闭
  • 菜单
  • Setting

L-Biopterin

L-生物喋呤,L-生物蝶呤
Catalog No.
C4833
生产许多神经递质和一氧化氮的辅因子
组合的产品项目
规格价格库存 数量
10mg
¥ 545.00
现货
25mg
¥ 1,181.00
现货
50mg
¥ 2,045.00
现货

电话: 021-55669583

邮箱: sales@apexbio.cn

全球经销商

A

背景

L-Biopterin is the oxidized form of tetrahydrobiopterin (BH4) [1].

Tetrahydrobiopterin (BH4) has been also known as sapropterin. BH4 is an essential cofactor of the three aromatic amino acid hydroxylase enzymes which has used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-HT), melatonin, norepinephrine, dopamine, epinephrine (adrenaline). BH4 is a cofactor of nitric oxide synthases [2].

L-Biopterin was reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. L-Biopterin was extremely toxic to human melanocytes in culture with the IC50 of 0.2 μM after 48 hrs. L-Biopterin was rarely existed under physiological conditions except in the epidermis of patients with the depigmentation disorder Vitiligo [3].

References:
[1] Schallreuter K U, Buttner G, Pittelkow M R, et al.  Cytotoxicity of 6-biopterin to human melanocytes[J]. Biochemical and biophysical research communications, 1994, 204(1): 43-48.
[2] Calka J.  The role of nitric oxide in the hypothalamic control of LHRH and oxytocin release, sexual behavior and aging of the LHRH and oxytocin neurons[J]. Folia Histochemica et Cytobiologica, 2006, 44(1): 3.
[3] Moore J, Wood J M, Schallreuter K U.  Evidence for Specific Complex Formation between α-Melanocyte Stimulating Hormone and 6 (R)-l-Erythro-5, 6, 7, 8-tetrahydrobiopterin using Near Infrared Fourier Transform Raman Spectroscopy[J]. Biochemistry, 1999, 38(46): 15317-15324.

化学属性

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt237.2
Cas No.22150-76-1
FormulaC9H11N5O3
SynonymsL-erythro-Biopterin,NSC 339699
Solubilityinsoluble in EtOH; insoluble in H2O; ≥4.55 mg/mL in DMSO with ultrasonic
Chemical Name2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4(1H)-pteridinone
SDFDownload SDF
Canonical SMILESNC(N=C1C2=NC([C@@H](O)[C@@H](O)C)=CN1[H])=NC2=O
运输条件 蓝冰运输或根据您的需求运输。
一般建议不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

质量控制

化学结构

L-Biopterin