Fucoidan
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Fucoidan, a type of complex carbohydrate called a polysaccrharide, is found in many forms of brown seaweed. Fucoidan has a variety of biological activities, including anticancer, antiviral, neuroprotective, and immune-modulating effects. It has been reported that fucoidan enhances the activities of natural killer (NK) cells which play a vital role in anti-cancer activity.
In vitro: Fucoidan triggered apoptosis of PC-3 cells, human prostate cancer cells, via evoking intrinsic and extrinsic signaling pathways in a dose-dependent fashion, which indicated that fucoidan could dose-dependently block the growth of PC-3 cells. The activation of apoptosis induced by fucoidan was involved in the inactivation of p38 MAPK and phosphatidylinositol 3-kinase (PI3K) /Akt, and the activation of extracellular signal-regulated kinase mitogen-activated protein kinase (ERK1/2 MAPK) [1].
In vivo: Female Balb/c mice bearing breast cancer were intraperitoneally injected with fucoidan at 10 mg/kg body weight every two days for 20 days. Fucoidan decreased the tumor volume and the tumor weight in Balb/c mice. Additionally, fucoidan triggered apoptosis, which indicated that fucoidan could exert a strong antitumor effect on breast cancer model. Compared with control group, fucoidan dampened angiogenesis in tumor tissue via inducing a remarkable decrease in intratumoral vascular endothelial growth factor expression and inhibited lung metastasis of breast cancer [2].
References:
[1]. Boo, H., Hong, J., Kim, S., Kang, J., Kim, M., & Kim, E. et al. The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells. Marine Drugs. 2013; 11(8): 2982-2999.
[2]. Xue, M., Ge, Y., Zhang, J., Wang, Q., Hou, L., & Liu, Y. et al. Anticancer Properties and Mechanisms of Fucoidan on Mouse Breast Cancer In Vitro and In Vivo. Plos ONE. 2012; 7(8). e43483.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | N/A |
Cas No. | 9072-19-9 |
Formula | (C6H9O3SO3)n |
Synonyms | Fucan,Sulfated α-L-Fucan |
Solubility | insoluble in EtOH; insoluble in H2O; ≥8.5 mg/mL in DMSO |
Chemical Name | (2S,3S,4S,5S,6R)-4-hydroxy-5-methoxy-2,6-dimethyltetrahydro-2H-pyran-3-yl hydrogen sulfate |
SDF | Download SDF |
Canonical SMILES | C[C@@H]1O[C@@](C)([H])[C@@H](OC)[C@H](O)[C@@H]1OS(O)(=O)=O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |