Flavin adenine dinucleotide
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 10mg | ￥454.00 | 现货 | |
| 50mg | ￥909.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Flavin adenine dinucleotide is used as a redox cofactor by a variety of proteins involved in several important enzymatic reactions in metabolism. In human, most flavoproteins contain one or more loosely bound flavin adenine dinucleotide moieties. Flavoproteins include the succinate dehydrogenase complex, α-ketoglutarate dehydrogenase, folate/FAD-dependent tRNA methyltransferases, N-hydroxylating flavoprotein monooxygenases, and apoptosis-inducing factor 2. Flavoproteins are predominately located in the mitochondria due to their redox power. Of all flavoproteins, more than 90% perform redox reactions and ~ 10% are lyases, transferases, isomerases and ligases involved in nonredox reactions.
References:
1. Kohlmeier M. Chapter 10 - Water-Soluble Vitamins and Nonnutrients. Nutrient Metabolism (Second Edition), 2015, 567-671.
2. Lienhart WD, Gudipati V, Macheroux P. The human flavoproteome. Archives of Biochemistry and Biophysics, 2013, 535(2): 150-162.
3. Macheroux P, Kappes B, Ealick SE. Flavogenomics--a genomic and structural view of flavin-dependent proteins. The FEBS Journal, 2011, 278(15): 2625-2634.
4. Sugiyama S, Ozawa T. Protection of chlorpromazine-induced arrhythmia by flavin-adenine-dinucleotide in canine heart. Japanese Heart Journal, 1979, 20(5): 657-665.
产品性质
| 物理外观 | A solid |
| CAS号 | 146-14-5 |
| 分子式 | C27H33P2N9O15 |
| 分子量 | 785.55 |
| 化学名称 | A name could not be generated for this structure. |
| 溶解度 | insoluble in EtOH; insoluble in DMSO; ≥196.5 mg/mL in H2O |
| SMILES | CC1=CC(N=C(C(O)=N2)C3=NC2=O)=C(N3C[C@@](O)([H])[C@@](O)([H])[C@@](O)([H])COP(O)(OP(O)(OC[C@](O4)([H])[C@](O)([H])[C@](O)([H])[C@]4([H])N5C=NC(C5=NC=N6)=C6N)=O)=O)C=C1C |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 黄素腺嘌呤二核苷酸（FAD）是一种氧化还原辅助因子，更确切地说，是一种蛋白质的修复基团，参与了新陈代谢中几个重要的酶促反应。 |
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