FG2216
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
FG-2216是强效的HIF脯氨酰羟化酶抑制剂,对PDH2酶的IC50为3.9 μM.
HIF(缺氧诱导因子)是由低氧气供应活化的转录因子,引起细胞\组织和生物体对缺氧的适应性反应,血红蛋白水平的增加与宫内缺氧有关.与其它转录共激活子共同作用,HIF诱导改善缺氧影响的基因转录,包括促红细胞生成素及其受体.
在猕猴中,FG-2216可逆激活内源性促红细胞生成素,60 mg/kg 剂量增加82倍到309倍,FG-2216口服给药后4小时,循环血浆促红细胞生成素的水平升高[1].
FG-2216慢性给药耐受性良好,并诱导猕猴中红细胞的生成.FG-2216也引起体内血红蛋白表达的小幅提升.慢性给药FG-2216开始后1至2周,动物体内含血红蛋白的网织红细胞的百分比(%F + retics)上升[1].
参考文献:
1. Hsieh MM, Linde NS, Wynter A et al. HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. Blood. 2007 Sep 15;110(6):2140-7.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 280.66 |
Cas No. | 223387-75-5 |
Formula | C12H9ClN2O4 |
Solubility | insoluble in H2O; ≥14.05 mg/mL in DMSO; ≥5.12 mg/mL in EtOH with ultrasonic |
Chemical Name | (Z)-2-(((1-chloro-4-hydroxyisoquinolin-3-yl)(hydroxy)methylene)amino)acetic acid |
SDF | Download SDF |
Canonical SMILES | ClC1=NC(/C(O)=N/CC(O)=O)=C(O)C2=CC=CC=C21 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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