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Fatostatin A

 
Catalog No.
B5599
固醇调节元件结合蛋白(SREBP)抑制剂
组合的产品项目
规格价格库存 数量
10mg
¥ 572.00
现货
50mg
¥ 1,781.00
现货

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A

背景

Fatostatin A is an inhibitor of sterol regulatory element binding protein (SREBP), which can inhibit the activation of SREBP-1 and SREBP-2[1].

Fatostatin A (0.1-1 μM; 3 days) inhibits the androgen-independent proliferation of prostate cancer cell in a manner independent of the known IGF1 signaling pathway. Fatostatin A inhibits insulin-induced fat formation in 3T3-L1 cells[2].

Fatostatin A (30 mg/kg; 150 mL; i.p.; daily for 28 days) prevents obese ob/ob mice from increasing their weight, blood sugar, and liver fat accumulation, even if they do not control the food intake of mice[1].

References:

[1]. Kamisuki S, et al. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol. 2009, 16(8): 882-92.

[2]. Choi Y, et al. Identification of bioactive molecules by adipogenesis profiling of organic compounds. J Biol Chem. 2003, 278(9): 7320-4.

化学属性

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt375.33
Cas No.298197-04-3
FormulaC18H18N2S·HBr
Solubilityinsoluble in H2O; ≥19.76 mg/mL in DMSO; ≥5.02 mg/mL in EtOH
Chemical Name2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole hydrobromide
SDFDownload SDF
Canonical SMILESCCCC1=NC=CC(C2=NC(C3=CC=C(C=C3)C)=CS2)=C1.Br
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