Entacapone sodium salt
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Entacapone，一种硝基儿茶酚化合物，是一种选择性的和可逆的儿茶酚-O-甲基转移酶（COMT，一种Mg2+依赖的参与儿茶酚胺和儿茶酚代谢的酶）抑制剂，半数最大有效抑制浓度IC50和抑制常数Ki值分别为20.1 nM和10.7 nM[1&2]。
在Entacapone的化学结构中，其硝基基团位于羟基基团邻位，其对entacapone抑制COMT的效力和能力是至关重要的部分[2]。
Entacapone是一种FDA批准的COMT抑制剂，作为一种辅助左旋多巴治疗帕金森病患者的药物，可同时增加左旋多巴在外周和中枢的可利用度[2]。
参考文献：
[1] Forsberg M, Lehtonen M, Heikkinen M, Savolainen J, Jrvinen T, Mnnist PT. Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat. J Pharmacol Exp Ther. 2003 Feb;304(2):498-506.
[2] Najib J. Entacapone: a catechol-O-methyltransferase inhibitor for the adjunctive treatment of Parkinson's disease. Clin Ther. 2001 Jun;23(6):802-32; discussion 771.
| Storage | Store at -20°C |
| M.Wt | 327.27 |
| Cas No. | 1047659-02-8 |
| Formula | C14H14N3NaO5 |
| Solubility | Soluble in DMSO |
| Chemical Name | sodium (E)-5-(2-cyano-3-(diethylamino)-3-oxoprop-1-en-1-yl)-2-hydroxy-3-nitrophenolate |
| SDF | Download SDF |
| Canonical SMILES | CCN(C(/C(C#N)=C([H])/C1=CC(N(=O)=O)=C(O)C([O-])=C1)=O)CC.[Na+] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
