DKM 2-93
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
DKM 2-93选择性抑制泛素样修饰激活酶5 (UBA5)，IC50值为430 μM。DKM 2-93不仅会损害PaCa2中胰腺癌细胞的存活，还会损害Panc1细胞，50%有效浓度值分别为90和30μM。在免疫缺陷小鼠的肿瘤异种移植研究中，每天使用DKM 2-93可以显着削弱体内PaCa2细胞的肿瘤生长，而不会导致任何体重减轻或显着毒性。
参考文献：
[1]. Roberts AM, et al. Chemoproteomic Screening of Covalent Ligands Reveals UBA5 As a Novel Pancreatic Cancer Target. ACS Chem Biol. 2017 Apr 21;12(4):899-904. PMID: 28186401
| Storage | Store at -20°C |
| M.Wt | 243.69 |
| Cas No. | 65836-72-8 |
| Formula | C11H14ClNO3 |
| Solubility | ≥27.2 mg/mL in DMSO |
| Chemical Name | 2-chloro-N-(3,4-dimethoxybenzyl)acetamide |
| SDF | Download SDF |
| Canonical SMILES | O=C(NCC1=CC=C(OC)C(OC)=C1)CCl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
