Dihydrodaidzein
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Dihydrodaidzein, an active, estrogenic metabolite of daidzein in colonic bacteria, probably is further metabolized to various bioactive compounds including equol. As an estrogen receptor agonist, dihydrodaidzein, at micromolar concentrations, activates the estrogen receptor-dependent growth of breast cancer cells. Daidzein, an isoflavonoid phytoestrogenic compound, is found in soybeans, clover, kudzu, and other legumes.
In vitro: Prostatic fluid and plasma concentrations of dihydrodaidzein were sufficient to block the growth of benign human prostatic epithelial cells (PrEC). Dihydrodaidzein showed a significant inhibitory effect on the growth of prostate cancer cell line LNCaP. Additionally, dihydrodaidzein slightly triggered the apoptosis of PrEC. In addition to affecting apoptosis, dihydrodaidzein decreased proliferation, which was associated with the changes in cell cycle distribution and Caspase 3 activation [1].
In vivo: Male C57B1/6 wild type mice were administered orally with dihydrodaidzein at a dose of 25 mg/kg/day for 4 weeks. Compared to the control groups, the neointima of mice treated with dihydrodaidzein was thickened. In dihydrodaidzein-treated mice, the intimal thickness in the non-injured right iliac artery was not altered. Moreover, neointimal proliferation was selectively blocked by dihydrodaidzein via suppressing the migration and proliferation of vascular smooth muscle cell and dampening the endothelial apoptosis [2].
References:
[1]. Hedlund, T., Bokhoven, A., Johannes, W., Nordeen, S., & Ogden, L. Prostatic fluid concentrations of isoflavonoids in soy consumers are sufficient to inhibit growth of benign and malignant prostatic epithelial cells in vitro. The Prostate. 2006; 66(5): 557-566.
[2]. Shen, J., White, M., Husband, A., Hambly, B., & Bao, S. Phytoestrogen derivatives differentially inhibit arterial neointimal proliferation in a mouse model. European Journal of Pharmacology. 2006; 548(1-3): 123-128.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 256.3 |
Cas No. | 17238-05-0 |
Formula | C15H12O4 |
Synonyms | (±)-Dihydrodaidzein,4',7-dihydroxy Isoflavanone |
Solubility | ≤0.1mg/ml in ethanol;30mg/ml in DMSO;10mg/ml in dimethyl formamide |
Chemical Name | 2,3-dihydro-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
SDF | Download SDF |
Canonical SMILES | OC(C=C1)=CC=C1C2C(C3=CC=C(O)C=C3OC2)=O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |