Dazoxiben hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Dazoxiben hydrochloride是一种有效且具有口服活性的血栓烷合成酶抑制剂，可抑制血小板和肾脏 TXB2 的产生以及 PG 内过氧化物代谢的相关变化。 Dazoxiben 抑制凝血人全血中 TXB2 的产生，IC50 为 0.3 mg/ml，并导致 PGE2 的平行增强大于 PGF2 α，大于 6-keto-PGF1 α 生成。 为了体外抑制大鼠肾小球中TXB2的生成, 需要比大鼠全血中（IC50=0.32 μg/ml）更高的浓度的Dazoxiben（IC50=1.60 μg/ml），并且与PGE2、PGF2α和6-keto-PGF1α生成的变化无关。
1. Patrignani P, et al. Differential effects of dazoxiben, a selective thromboxane-synthase inhibitor, on platelet and renal prostaglandin-endoperoxide metabolism. J Pharmacol Exp Ther. 1984 Feb;228(2):472-7.
| Storage | Store at -20°C |
| M.Wt | 268.7 |
| Cas No. | 74226-22-5 |
| Formula | C12H13ClN2O3 |
| Solubility | ≥28.4 mg/mL in DMSO |
| Chemical Name | 4-(2-(1H-imidazol-1-yl)ethoxy)benzoic acid hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | OC(C1=CC=C(C=C1)OCCN2C=NC=C2)=O.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
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化学结构
