D-Lin-MC3-DMA
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
siRNA-based drugs need a complicated delivery vehicle, that’s because it degraded rapidly in the circulation, difficult to cross the cell membranes and enter the cytoplasm, plus inefficient accumulation in target tissues. The major delivery technology for siRNA is the lipid nanoparticle (LNP) containing ionizable amino lipid, which is the consisted of an ionizable amino lipid (heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate, DLin-MC3-DMA), a phosphatidylcholine (1,2-distearoyl-sn-glycero-3-phosphocholine, DSPC), cholesterol and a coat lipid (polyethylene glycol-dimyristolglycerol, PEG-DMG). As a potent siRNA delivery vehicle, DLin-MC3-DMA is 1000-fold more potent for silencing of a hepatic gene (Factor VII), comparing to its precursor lipid DLin-DMA. The ED50 for LNP containing DLin-MC3-DMA to silence Factor VII was 0.005 mg/kg for mice, and 0.03 mg/kg for TTR in non-human primates.
Reference:
Tam YY, Chen S, Cullis PR. Advances in Lipid Nanoparticles for siRNA Delivery. Pharmaceutics. 2013 Sep 18;5(3):498-507. PMID: 24300520.
| Storage | Store at -20°C or below |
| M.Wt | 642.09 |
| Cas No. | 1224606-06-7 |
| Formula | C43H79NO2 |
| Synonyms | Dlin-MC3-DMA; DLin |
| Solubility | insoluble in H2O; insoluble in DMSO; ≥152.6 mg/mL in EtOH |
| Chemical Name | (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate |
| SDF | Download SDF |
| Canonical SMILES | O=C(CCCN(C)C)OC(CCCCCCCC/C=C\C/C=C\CCCCC)CCCCCCCC/C=C\C/C=C\CCCCC |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
