Cyclic di-GMP
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Cyclic-di-GMP 是 STING 的激动剂也是一个可以调节不同细菌物种的生物膜形成、运动性和毒力的第二信使。
References :
[1]. Nakamura T, et al. Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J Control Release. 2015 Oct 28;216:149-57.
[2]. Burdette DL, et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 2011 Sep 25;478(7370):515-8.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 690.41 |
| Cas No. | 61093-23-0 |
| Formula | C20H24N10O14P2 |
| Solubility | insoluble in DMSO; insoluble in EtOH; ≥20.85 mg/mL in H2O |
| Chemical Name | 9,9'-((2R,3R,3aS,7aR,9R,10R,10aS,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidodecahydrodifuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl)bis(2-amino-1H-purin-6(9H)-one) |
| SDF | Download SDF |
| Canonical SMILES | O=C1NC(N)=NC2=C1N=CN2[C@H](O[C@@]([C@@]3([H])OP(O)(OC[C@]([C@@]4([H])OP5(O)=O)(O[C@@H](N6C(N=C(N)NC7=O)=C7N=C6)[C@@H]4O)[H])=O)(CO5)[H])[C@@H]3O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
