Cinacalcet HCl
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Cinacalcet HCl（AMG 073）作为第二代钙受体激动剂，是一种强效的钙敏感受体（CAR）激动剂，EC50值为2.8 μM [ 1 ]。
盐酸西那卡塞（Cinacalcet HCl）对继发性甲状旁腺功能亢进症的治疗是安全的。另外，Cinacalcet HCl已被证明在降低钙磷乘积和血磷水平的同时，也能显著降低甲状旁腺激素（PTH）的水平[ 1 ]。
对Rice H-500肿瘤荷瘤小鼠口服给药，Cinacalcet HCl显著地降低血液钙离子、血清总钙浓度和血清甲状旁腺激素相关肽（PTHrP）的水平[ 2 ]。
参考文献：
[1] Urea P1, Frazo JM. Calcimimetic agents: review and perspectives. Kidney Int Suppl. 2003 Jun, (85): S91-6.
[2] Colloton M1, Shatzen E, Wiemann B, Starnes C, Scully S, Henley C, Martin D. Cinacalcet attenuates hypercalcemia observed in mice bearing either Rice H-500 Leydig cell or C26-DCT colon tumors. Eur J Pharmacol. 2013 Jul 15, 712(1-3): 8-15.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 393.87 |
| Cas No. | 364782-34-3 |
| Formula | C22H23ClF3N |
| Solubility | insoluble in H2O; ≥17.85 mg/mL in DMSO; ≥56 mg/mL in EtOH |
| Chemical Name | N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine;hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
