CD 2314
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
CD 2314是RARβ的强效选择性激动剂,对RARβ和RARα受体的Kd值分别为145和大于3760 nM[1].
维甲酸受体β(RARβ)是维甲酸的核受体,位于细胞质和亚核隔室中.RARβ介导细胞生长\分化和胚胎形态发生的细胞信号.
CD 2314是RARβ的有效选择性激动剂.由于胸腺中缺乏RARβ,CD 2314不抑制胸腺细胞中活化诱导的凋亡[1].CD 2314抑制细胞生长,对人头颈部鳞状细胞癌(HNSCC)22A\22B\183A和886细胞系的IC50值分别为8.0\3.0\5.7和大于10 μM.在UMSC22B细胞中,CD2314与RXR选择性的类视黄醇组合使用,如SR11234\SR11203\SR11246和SR11236,可抑制细胞生长[2].在KG-1细胞中,CD 2314不诱导叶酸受体β(FR-β)的表达,这表明FR-β的诱导不是由RARβ介导的[3].
参考文献：
[1]. Szondy Z, Reichert U, Bernardon JM, et al. Inhibition of activation-induced apoptosis of thymocytes by all-trans- and 9-cis-retinoic acid is mediated via retinoic acid receptor alpha. Biochem J, 1998, 331 ( Pt 3): 767-774.
[2]. Sun SY, Yue P, Mao L, et al. Identification of receptor-selective retinoids that are potent inhibitors of the growth of human head and neck squamous cell carcinoma cells. Clin Cancer Res, 2000, 6(4): 1563-1573.
[3]. Xu Y, Wang T, Tang R, et al. All-trans retinoic acid is capable of inducing folate receptor β expression in KG-1 cells. Tumour Biol, 2010, 31(6): 589-595.
| Physical Appearance | White solid |
| Storage | Store at -20°C |
| M.Wt | 364.5 |
| Cas No. | 170355-37-0 |
| Formula | C23H24O2S |
| Solubility | <36.45mg/ml in DMSO |
| Chemical Name | 5-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydroanthracen-2-yl)thiophene-3-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | CC(CCC1(C)C)(C2=C1C=C3C=C(C4=CC(C(O)=O)=CS4)C=CC3=C2)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
