BMS 961
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
BMS961是有效的视黄酸受体gamma(RARγ)选择性激动剂,IC50值为30 nM。
RARγ属于核受体家族,可调节转录。在癌细胞如神经母细胞瘤细胞中,RARγ介导视黄醇的抗增值和凋亡作用。RARγ是角化细胞中调控RA介导的生长停滞的主要受体。
在体外,在小鼠耳皮肤中使用BMS961可引起胸腺基质淋巴细胞(TSLP)转录子的显著增加[1]。此外,四肢暴露于低浓度的BMS861可引起zeugopod(长骨)生长迟缓和autopod(爪)的完整性。然而,高浓度的BMS961治疗可引起两个肢体区域同等的未分化[2]。
在WT小鼠中,RARγ激动剂BMS961治疗可引起耳TSLP转录子和血浆TSLP增加,表明RAR介导的事件参与TSLP表达的转录激活[1]。
参考文献:
1. Li M, Hener P, Zhang Z, et al. Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proceedings of the National Academy of Sciences of the United States of America. 2006;103(31):11736-11741.
2. Galdones E, Hales BF. Retinoic acid receptor gamma-induced misregulation of chondrogenesis in the murine limb bud in vitro. Toxicological sciences : an official journal of the Society of Toxicology. 2008;106(1):223-232.
Physical Appearance | Off-white solid |
Storage | Store at -20°C |
M.Wt | 399.46 |
Cas No. | 185629-22-5 |
Formula | C23H26FNO4 |
Solubility | <39.95mg/ml in DMSO |
Chemical Name | (S)-3-fluoro-4-(2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)acetamido)benzoic acid |
SDF | Download SDF |
Canonical SMILES | FC1=CC(C(O)=O)=CC=C1NC([C@H](C2=CC=C3C(C)(C)CCC(C)(C)C3=C2)O)=O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |