BAY-X 1005
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
BAY-X1005是5-脂氧合酶激活蛋白的选择性抑制剂[1].
5-脂氧合酶激活蛋白(FLAP)是一个整合蛋白,在5-脂氧合酶(5-LOX)的活化和白三烯的合成中起重要作用,从而调节免疫应答.
BAY-X1005是白三烯合成的选择性抑制剂.BAY-X1005结合FLAP并抑制5-LOX从细胞质易位到细胞膜[1].BAY-X1005抑制LTB4合成,在人\大鼠和小鼠中分离的PMNL的IC50值分别为0.22\0.026和0.039 μM,抑制小鼠巨噬细胞LTC4的合成,IC50值为0.021 μM [2].
在花生四烯酸诱导的小鼠耳炎症试验中,BAY-X1005抑制髓过氧化物酶活性和水肿的形成,ED50值分别为7.9和48.7[2].
此外,100 mg/kg 的BAY-X1005以剂量依赖的方式将血小板活化因子诱导的小鼠死亡降低了51％.在动物模型中,BAY-X1005抑制LTB4和LTC4的合成,从而降低水肿形成以及血管中炎症和白细胞迁移[3].
参考文献：
[1]. Hatzelmann A, Fruchtmann R, Mohrs KH, et al. Mode of action of the leukotriene synthesis (FLAP) inhibitor BAY X 1005: implications for biological regulation of 5-lipoxygenase. Agents Actions, 1994, 43(1-2): 64-68.
[2]. Müller-Peddinghaus R, Fruchtmann R, Ahr HJ, et al. BAY X1005, a new selective inhibitor of leukotriene synthesis: pharmacology and pharmacokinetics. J Lipid Mediat, 1993, 6(1-3): 245-248.
[3]. Müller-Peddinghaus R, Kohlsdorfer C, Theisen-Popp P, et al. BAY X1005, a new inhibitor of leukotriene synthesis: in vivo inflammation pharmacology and pharmacokinetics. J Pharmacol Exp Ther, 1993, 267(1): 51-57.
| Physical Appearance | Beige solid |
| Storage | Store at RT |
| M.Wt | 361.43 |
| Cas No. | 128253-31-6 |
| Formula | C23H23NO3 |
| Solubility | <36.14mg/ml in DMSO |
| Chemical Name | (S)-2-cyclopentyl-2-(4-(quinolin-2-ylmethoxy)phenyl)acetic acid |
| SDF | Download SDF |
| Canonical SMILES | OC([C@H](C(C=C1)=CC=C1OCC2=NC3=CC=CC=C3C=C2)C4CCCC4)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
