Balicatib
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Balicatib是一种组织蛋白酶K抑制剂,IC50值为1.4 nM[1].
在体外酶试验中,相比组织蛋白酶B\L和S,balicatib对组织蛋白酶K具有高选择性.然而,在基于细胞的酶试验中,选择性没那么高.Balicatib的溶酶体特性使其在溶酶体中积累及随后的非选择性脱靶效应.Balicatib的这种脱靶效应也可引起皮肤不良反应[1,2].
作为组织蛋白酶K的抑制剂,balicatib被开发用于治疗骨质疏松症.据报道,在切除卵巢的猴子中,balicatib减少骨吸收的生化标志物,并增加骨密度.此外,balicatib对绝经后妇女的新骨形成有益[2].
参考文献：
[1] Black WC. Peptidomimetic inhibitors of cathepsin K. 2010;10(7):745-51.
[2] Brmme D, Lecaille F. Cathepsin K inhibitors for osteoporosis and potential off-target effects. Expert Opin Investig Drugs. 2009 May;18(5):585-600.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 411.54 |
| Cas No. | 354813-19-7 |
| Formula | C23H33N5O2 |
| Solubility | ≥17 mg/mL in DMSO; insoluble in H2O; ≥2.54 mg/mL in EtOH with gentle warming and ultrasonic |
| Chemical Name | N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamide |
| SDF | Download SDF |
| Canonical SMILES | CCCN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3(CCCCC3)C(=O)NCC#N |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
