ARP 101
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
ARP101是MMP-2的选择性抑制剂，IC50值为0.81 nM。
在正常生理过程，如胚胎发育、生殖和组织重塑，以及疾病过程，如关节炎和癌转移中，MMP-2酶参与细胞外基质的降解[1]。
体外实验表明，ARP101可以抑制纤维肉瘤HT1080细胞的生长。ARP101对MMP-2的选择性大约是MMP-1的250倍，对MMP-9的选择性约是MMP-1的100倍[2]。ARP101对MMP-2的效能是compound a 和CGS 27023A的15.3和24.7倍，与抑制剂普啉司他（Prinomastat）和CGS27023A相比，ARP101对MMP-2 / MMP-1具有不同的选择性和效能[3]。
参考文献：
[1]. Page-McCaw A, Ewald AJ, Werb Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol, 2007, 8(3): 221-33.
[2]. Rossello A, Nuti E, Orlandini E, et al. New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2). Bioorg Med Chem, 2004, 12(9): 2441-50.
[3]. Tuccinardi T, Martinelli A, Nuti E, et al. Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3 methylbutanamides. Bioorg Med Chem, 2004, 14: 4260-4276.
| Physical Appearance | White solid |
| Storage | Desiccate at 4°C |
| M.Wt | 406.5 |
| Cas No. | 849773-63-3 |
| Formula | C20H26N2O5S |
| Solubility | <40.65mg/ml in DMSO; <10.16mg/ml in ethanol |
| Chemical Name | (R)-N-hydroxy-2-(N-isopropoxy-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanamide |
| SDF | Download SDF |
| Canonical SMILES | CC(C)[C@@H](N(OC(C)C)S(=O)(C1=CC=C(C2=CC=CC=C2)C=C1)=O)C(NO)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
相关生物数据
