AR7
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
AR7是非典型的 RARA/RARα (视黄酸受体α)拮抗剂。AR7特异性激活伴侣介导的自噬(CMA)活性，而不会影响自噬[1]。
用RARA拮抗剂AR7（20 μM；持续16小时）处理可增加WT和LRRK2R1441G KI突变体MEF中的溶酶体活性[1]。AR7（10、20、30 uM；12、24小时）对NIH 3T3细胞中的巨自噬没有影响[2]。
参考文献：
[1]. Ho PW, Leung CT, Liu H, Pang SY, Lam CS, Xian J, Li L, Kung MH, Ramsden DB, Ho SL. Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). Autophagy. 2020 Feb;16(2):347-370. doi: 10.1080/15548627.2019.1603545. Epub 2019 Apr 14. PMID: 30983487; PMCID: PMC6984454.
[2]. Bourdenx M, Martín-Segura A, Scrivo A, Rodriguez-Navarro JA, Kaushik S, Tasset I, Diaz A, Storm NJ, Xin Q, Juste YR, Stevenson E, Luengo E, Clement CC, Choi SJ, Krogan NJ, Mosharov EV, Santambrogio L, Grueninger F, Collin L, Swaney DL, Sulzer D, Gavathiotis E, Cuervo AM. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021 May 13;184(10):2696-2714.e25. doi: 10.1016/j.cell.2021.03.048. Epub 2021 Apr 22. PMID: 33891876; PMCID: PMC8152331.
| Storage | Store at -20°C |
| M.Wt | 257.72 |
| Cas No. | 80306-38-3 |
| Formula | C15H12ClNO |
| Solubility | ≥6.05 mg/mL in DMSO with ultrasonic |
| Chemical Name | 7-chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine |
| SDF | Download SDF |
| Canonical SMILES | CC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
