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Amidepsine D

 
Catalog No.
C4875
DGAT抑制剂
组合的产品项目
规格价格库存 数量
1mg
¥ 4,116.00
Ship with 10-15 days
2.5mg
¥ 8,179.00
Ship with 10-15 days

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背景

Amidepsine D is a fungal metabolite isolated from the culture broth of Humicola sp FO-2942. Amidepsine A is an inhibitor of dylglycerol acyltransferase (DGAT).

Dylglycerol acyltransferase (DGAT) has been involved in catalyzing the formation of triglycerides from diacylglycerol and Acyl-CoA. The reaction is considered the terminal and only committed step in triglyceride synthesis and is essential for the formation of adipose tissue. There are two isozymes of DGAT have been identified: DGAT1 and DGAT2. DGAT-1 deficient mice are lean and resistant to the development of diet-induced obesity or insulin resistance [1]. DGAT2-/- mice demonstrate reduced triglyceride levels and suffer from skin barrier abnormalities [2].

FO-2942 inhibited DGAT activity with an IC50 of 10.2 μM in rat liver microsomes. FO-2942 inhibited triacylglycerol formation in Raji cells with the IC50 value of 15.5 μM [1].

References:
[1] Tomoda H, Tabata N, Ito M, et al.  Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942[J]. The Journal of antibiotics, 1995, 48(9): 942-947.
[2] Smith S J, Cases S, Jensen D R, et al.  Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat[J]. Nature genetics, 2000, 25(1): 87-90.
[3] Stone S J, Myers H M, Watkins S M, et al.  Lipopenia and skin barrier abnormalities in DGAT2-deficient mice[J]. Journal of Biological chemistry, 2004, 279(12): 11767-11776.

化学属性

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt496.5
Cas No.79786-34-8
FormulaC26H24O10
SolubilitySoluble in DMSO
Chemical Name4-[(2,4-dimethoxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methyl-benzoic acid, 4-carboxy-3-hydroxy-5-methylphenyl ester
SDFDownload SDF
Canonical SMILESOC1=C(C(O)=O)C(C)=CC(OC(C2=C(O)C=C(OC(C3=C(C)C=C(OC)C=C3OC)=O)C=C2C)=O)=C1
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质量控制

质量控制和MSDS

批次:

化学结构

Amidepsine D