Acetaminophen
COX抑制剂
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 1mL(10 mM in DMSO) | ￥500.00 | 现货 | |
| 5g | ￥381.00 | 现货 | |
| 10g | ￥518.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with IC50 of 25.8 μM, It is a widely used antipyretic analgesic[1].
Paracetamol (50 mM) significantly reduces cell viability. But co-treatment with acetaminophen and HV110 can significantly increase cell viability[2].
Paracetamol (250 mg / kg) reduces glutathione levels and glutathione peroxidase activity in mice, and induces mast cell death and hypertrophy in primary mouse liver cells The inhibitor ferrostatin-1 can block this effect. Paracetamol has analgesic and antipyretic effects in animal models.
References:
[1]. Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man, 2008, 22(2): 383-90.
[2]. Dini M, et al. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Front Microbiol, 2017, 8: 594.
[3]. Lőrincz T, Jemnitz K, Kardon T, et al. Ferroptosis is Involved in Acetaminophen Induced Cell Death. Pathology & Oncology Research, 2015, 21(4): 1115-1121.
产品性质
| 物理外观 | A solid |
| CAS号 | 103-90-2 |
| 分子式 | C8H9NO2 |
| 分子量 | 151.16 |
| 化学名称 | (Z)-N-(4-hydroxyphenyl)acetimidic acid |
| 溶解度 | insoluble in H2O; ≥29.4 mg/mL in EtOH; ≥7.56 mg/mL in DMSO |
| SMILES | C/C(\O)=N/c(cc1)ccc1O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 对乙酰氨基酚（APAP）是一种 COX 抑制剂；可抑制 COX-1 和 COX-2（IC50=113.7/25.8 muM）。对乙酰氨基酚具有解热镇痛活性和微弱的抗炎活性。 |
生物相关数据
质量控制
操作说明
APExBIO 顾客使用本产品发表的 1 篇科研文献
- 1. Jing Chu, Yi Jiang, et al. "Acetaminophen alleviates ferroptosis in mice with sepsis-associated encephalopathy via the GPX4 pathway." Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221133547. PMID: 36214461
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