2-Deoxycytidine
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
2-Deoxycytidine is a cytidine analog.
2-Deoxycytidine prevents DNA methylation by incorporating itself into newly synthesizing DNA strand. 2-Deoxycytidine also binds to DNA methyltransferase irreversibly and hinders its activity. Thus, 2-deoxycytidine was approved as the most efective demethylating agent for the treatment of cancer .
2-Deoxycytidine at clinically achievable and nontoxic concentrations (≥ 100 μmol/L) protected normal bone marrow progenitor cells against the inhibitory effects of co-administered, high concentrations of 3’-azido-3’-deoxythymidine (AZT) (≥ 10 μmol/L). In normal bone marrow mononuclear cells (BMMC), 2-deoxycytidine also significantly corrected AZT-mediated depletion of intracellular thymidine triphosphate and 2-deoxycytidine triphosphate levels. Furthermore, 2-deoxycytidine reduced the intracellular accumulation of AZT triphosphate and its DNA incorporation in BMMC .
In a rat model of myocardial infarction induced by ligating left anterior descending coronary artery, human umbilical cord mesenchymal stem cells treated with 2-deoxycytidine(5, 10, 20 and 40 µM) before transplantation to the left ventricular wall immediately after ligation significantly improved the cardiac systolic and diastolic functions, and pumping ability. Fibrotic area and left ventricular wall thickness were also significantly improved .
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 227.22 |
Cas No. | 951-77-9 |
Formula | C9H13N3O4+adduct |
Solubility | ≥22.7 mg/mL in DMSO; insoluble in EtOH; ≥48 mg/mL in H2O |
Chemical Name | 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-imino-1,4-dihydropyrimidin-2-ol |
SDF | Download SDF |
Canonical SMILES | N=C1C=CN(C(O)=N1)[C@@]2([H])C[C@@](O)([H])[C@@](O2)([H])CO |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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