Apoptosis
Apoptosis, also known as programmed cell death, is rigorously controlled process of cell death that leads to phagocytosis of unwanted cell. It is triggered after sufficient cellular damage and activated through extrinsic or intrinsic pathways. The intrinsic pathway is mainly occurs via release of cytochrome c from the mitochondria and regulates mitochondrial outer membrane permeabilization by Bcl-2 family proteins. The extrinsic pathway is induced by ligand binding to death receptor, such as Fas, TNFαR, DR3, DR4, and DR5. Caspases then cleave target proteins and nuclear lamins to promote DNA degradation, resulting apoptotic cells undergo phagocytosis. In addition, p53 has the ability to activate intrinsic and extrinsic pathways of apoptosis by inducing transcription of several proteins like Puma, Bid, Bax, TRAIL-R2, and CD95.
Some Inhibitors of apoptosis proteins (IAPs), such as XIAP/BIRC4 and Bruce/BIRC6, can block casapse activity through direct binding, while other IAPs, such as cIAP1/BIRC2, cIAP2/BIRC3, act as ubiquitin ligases that target caspases for ubiquitin-mediated degradation. Apoptosis is essential for growth, development and aging in multicellular organisms. Any alterations or abnormalities occurring in apoptotic processes contribute to development of human diseases, including cancer.
- C3296 MPI-0441138Summary: 凋亡和生长抑制的诱导剂
- C3234 2-HBASummary: Keap1-Nrf2-ARE通路中催化解毒反应的酶的间接诱导剂
- C3192 CBL0137 (hydrochloride)Summary: 激活p53并抑制NF-κB
- C3171 CBL0137Summary: 激活p53并抑制NF-κB
- C3129 R-7050Summary: TNF-α受体信号拮抗剂,细胞可通透
- C3058 ML-354Summary: PAR4拮抗剂
- B7812 Selonsertib (GS-4997)中文名: 司隆色替,瑟隆舍替Summary: 凋亡信号调节激酶1(ASK1)抑制剂
- B6198 ReACp53Summary: 抑制p53淀粉样蛋白形成
- B6194 GSK481Summary: RIP1(受体相互作用蛋白激酶1)抑制剂
- B6191 PD-1/PD-L1 Inhibitor 3Summary: PD-1/PD-L1相互作用抑制剂