WIN 64338 hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
WIN 64338 hydrochloride是一种有效的和竞争性的缓激肽B2受体拮抗剂[1]。
缓激肽B2受体是一种G蛋白偶联受体，被缓激肽所激活。缓激肽是一种炎症性九肽，在水肿、血管舒张、疼痛纤维刺激和平滑肌痉挛中起关键作用。
WIN 64338 hydrochloride是一种有效的和竞争性的缓激肽B2受体拮抗剂。在人IMR-90细胞中，WIN 64338抑制缓激肽与缓激肽B2受体的结合，Ki值为64 nM，还以竞争的方式抑制缓激肽刺激的Ca2+外流，pA2值为7.1。WIN 64338抑制缓激肽诱导的豚鼠回肠收缩，pA2值为8.2，也抑制乙酰胆碱诱导的收缩[1]。在从兔子中分离的虹膜括约肌中，WIN 64338 （1-10 μM）抑制缓激肽诱发的收缩反应，pKB值为6.6[2]。在豚鼠气管平滑肌细胞中，WIN 64338抑制缓激肽诱导的磷酸肌醇的形成[3]。
在豚鼠中，WIN 64338（30 nM）通过三叉神经中速激肽的释放，显著抑制缓激肽诱导的血浆外渗的增加[2]。
参考文献：
[1]. Sawutz DG, Salvino JM, Dolle RE, et al. The nonpeptide WIN 64338 is a bradykinin B2 receptor antagonist. Proc Natl Acad Sci U S A, 1994, 91(11): 4693-4697.
[2]. Hall JM, Figini M, Butt SK, et al. Inhibition of bradykinin-evoked trigeminal nerve stimulation by the non-peptide bradykinin B2 receptor antagonist WIN 64338 in vivo and in vitro. Br J Pharmacol, 1995, 116(8): 3164-3168.
[3]. Scherrer D, Schmidlin F, Lach E, et al. Effect of WIN 64338, a B2 bradykinin receptor antagonist on guinea-pig tracheal smooth muscle cells in culture. Fundam Clin Pharmacol, 1998, 12(2): 188-193.
| Physical Appearance | White solid |
| Storage | Store at -20°C |
| M.Wt | 783.95 |
| Cas No. | 163727-74-0 |
| Formula | C45H68ClN4OP·HCl |
| Solubility | <58.8mg/ml in DMSO |
| Chemical Name | (S,E)-(N,N'-dicyclohexylcarbamimidoyl)(3-(naphthalen-2-yl)-1-oxo-1-((4-((tributylphosphonio)methyl)phenyl)amino)propan-2-yl)amide dihydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CCCC[P+](CCCC)(CC1=CC=C(NC([C@]([N-]/C(NC2CCCCC2)=N\C3CCCCC3)([H])CC4=CC5=CC=CC=C5C=C4)=O)C=C1)CCCC.Cl.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
