Catalog No. B6890

U 46619

Name: U 46619, U-46619, 56985-40-1
Brand: APExBIO
SKU: B6890
Price: 2255 CNY
Availability: InStock

（别名：U-46619）

前列腺素H2（PGH2）/血栓素A2（TxA2）（TP）受体激动剂

规格	价格	货期
1mg	￥2255.00	现货
5mg	￥7365.00	现货
10mg	￥13005.00	现货

CAS号：56985-40-1纯度：98%

仅用于科研，不用于诊疗。未经明确授权不得转售。

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Phos binding reagent (Phosbind) acrylamide

分离和检测磷酸化/非磷酸化蛋白

- 新型的磷酸盐结合标签和功能分子
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Cell Counting Kit-8 (CCK-8)

用于细胞增殖和细胞毒性试验

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Cy5 TSA Fluorescence System Kit

Cy5荧光标记的酪胺信号放大系统

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HotStart™ 2X Green qPCR Master Mix

用于荧光定量目标DNA或cDNA

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高效的Cy5修饰RNA转录试剂盒

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产品描述产品性质产品应用生物相关数据质量控制操作说明产品引用文献摩尔浓度计算器

产品描述

EC50：作用于形状变化为0.035 μM、作用于MLCP为0.057 μM、作用于血清素释放为0.536 μM、作用于聚集为0.057 μM，作用于纤维蛋白原受体结合为0.53 μM [3]。

前列腺素内过氧化物类似物U46619（11,9环氧乙烷-前列腺素H2）是一种选择性的前列腺素H2（PGH2/血栓素A2（TxA2）（TP）受体激动剂。PGH2和TxA2受体都是G-蛋白偶联受体。

体外：U46619对人血小板显示双相效应。在该化合物浓度低时，发生形状变化和MLCP（EC50 = 0.035 μM和0.057 μM）；而在该化合物浓度较高时，发生血清素释放和血小板聚集（EC50 = 0.536 μM和1.31 μM）。对血小板形状变化和MLCP的效应由受体介导[3]。

体内：U46619通过激活ETA和ETB受体，引起大鼠肾皮质血管收缩和髓质血管舒张[2]。在清醒SHR（自发性高血压大鼠）中，1-100 nmol/kg U-46619 (i.c.v.)诱导剂量相关性的血压增加，但对心率没有显著影响[1]。

临床试验：目前尚未进行临床研究。

参考文献：
[1] Sirén AL, SvartstrμM-Fraser M, Paakkari I. Central cardiovascular effects of the endoperoxide analogue U-46619 in rats. Prostaglandins Leukot Med. 1985 Mar;17(3):381-6.
[2] Hantz H, Adesuyi A, Adebayo O. Differential effects of U46619 on renal regional hemodynamics in the rat: involvement of endothelin. J Pharmacol Exp Ther. 2001 Oct;299(1):372-6.
[3] Morinelli TA1, Niewiarowski S, Daniel JL, Smith JB. Receptor-mediated effects of a PGH2 analogue (U 46619) on human platelets. Am J Physiol. 1987 Nov;253(5 Pt 2):H1035-43.

产品性质

物理外观	A solution in methyl acetate, learn about Variance in Solubility
CAS号	56985-40-1
分子式	C₂₁H₃₄O₄
分子量	350.5
小分子别名	U-46619
化学名称	(E)-7-((1R,4R,5S,6R)-6-((S,Z)-3-hydroxyoct-1-en-1-yl)-2-oxabicyclo[2.2.1]heptan-5-yl)hept-5-enoic acid
溶解度	≥100 mg/mL in DMSO, ≥100 mg/mL in Ethanol, ≥100 mg/mL in DMF, ≥2 mg/mL in PBS pH 7.2
SMILES	CCCCC[C@@H](/C=C\[C@H]1[C@@H](C2)OC[C@H]2[C@@H]1C/C=C/CCCC(O)=O)O
存储条件	-20°C
运输条件	蓝冰

产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)

IC50和靶点

生物活性描述

U-46619 是一种有效的血栓素 A2（TXA2）激动剂和血栓素 A2 类似物（内过氧化物），能够诱导肌球蛋白轻链 9（Myl9）基因缺失小鼠的主动脉平滑肌（SM）收缩。

生物相关数据

质量控制

请选择批次查看:

纯度 = 98.00%

COA (Certificate Of Analysis)MSDS (Material Safety Data Sheet)

操作说明

Datasheet 小分子化合物通用使用指南

APExBIO 顾客使用本产品发表的 13 篇科研文献

1. Meiying Huang, Luhao Wang, et al. "rhBNP inhibited ferroptosis in renal ischemia-reperfusion injury through promoting selenium recycling." Free Radic Biol Med. 2025 Dec 31:S0891-5849(25)01473-X. PMID: 41482081

2. Xi-Xi Hou, Shuang Wang, et al. "Design, Synthesis, and Biological Evaluation of Novel Hydroxytyrosol Derivatives as Protectors for Vascular Endothelium Against Lipid Overload." Drug Des Devel Ther. 2025 Apr 1:19:2433-2452. PMID: 40190807

3. Xi Chen, Xin Chen, et al. "GV-971 prevents severe acute pancreatitis by remodeling the microbiota-metabolic-immune axis." Nat Commun. 2024 Sep 27;15(1):8278. PMID: 39333064

4. Zhixiang Zhu, Yanggan Luo, et al. "Icaritin Sensitizes Thrombin-and TxA2-Induced Platelet Activation and Promotes Hemostasis via Enhancing PLCγ2-PKC Signaling Pathways." Thromb Haemost. 2024 Feb 9. PMID: 38224965

5. Cheng Wei, Jishou Zhang, et al. "Resolvin D1 attenuates Ang II-induced hypertension in mice by inhibiting the proliferation, migration and phenotypic transformation of vascular smooth muscle cells by blocking the RhoA/mitogen-activated protein kinase pathway." J Hypertens. 2023 Nov 7. PMID: 37937508

6. JQingfeng Yu, Chengjie Wu, et al. "Inhibition of LIM kinase reduces contraction and proliferation in bladder smooth muscle." Acta Pharm Sin B. 2021 Jul;11(7):1914-1930. PMID: 34386328

7. Fengyang Li, Dan Xu, et al. "Pretreatment of Indobufen and Aspirin and their Combinations with Clopidogrel or Ticagrelor Alleviates Inflammasome Mediated Pyroptosis Via Inhibiting NF-κB/NLRP3 Pathway in Ischemic Stroke." J Neuroimmune Pharmacol. 2021 Dec;16(4):835-853. PMID: 33512659

8. Xu Li, Gaoqing Xu, et al. "Gonadotropin-inhibiting hormone promotes apoptosis of bovine ovary granulosa cells." Life Sci. 2021 Apr 1;270:119063. PMID: 33460664

9. Xiao J, Wang F, et al. "Targeting the COX2/MET/TOPK signaling axis induces apoptosis in gefitinib-resistant NSCLC cells." Cell Death Dis. 2019 Oct 14;10(10):777. PMID: 31611604

10. Luo Y, Teng X, et al. "CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension." Nat Commun. 2019 Aug 7;10(1):3551. PMID: 31391533

11. Yan YY, Ao LY, et al. "Therapeutic effects of JLX001 on cerebral ischemia through inhibiting platelet activation and thrombus formation in rats." Biomed Pharmacother. 2018 Jul 7;106:805-812. PMID: 29990874

12. Zhang Q, Tan C, et al. "Characterization of active antiplatelet chemical compositions of edible Citrus limon through ultra-performance liquid chromatography single quadrupole mass spectrometry-based chemometrics." Food Funct. 2018 Apr 24

13. Zhang Q, Tan CN, et al. "Adsorbed hollow fiber-based biological fingerprinting for the discovery of platelet aggregation inhibitors from Danshen-Honghua decoction." J Sep Sci. 2018 Mar 23. PMID: 29573136